The S and s antigens were reported in 1947 and 1951 respectively and form part of the MNS system. Anti-S and anti-s have both been implicated in Haemolytic Transfusion Reactions and Haemolytic Disease of the Newborn.

The reagents will cause indirect agglutination (clumping) of test red cells, that carry the corresponding specific antigen, in the antiglobulin phase of testing. No agglutination generally indicates the absence of the corresponding specific antigen.

Lorne Monoclonal Anti-S blood grouping reagent contains human monoclonal antibodies diluted in a phosphate buffer containing sodium chloride and bovine albumin. It is supplied at optimal dilution for use with indirect Coombs tube test & gel card techniques.