The S and s antigens were reported in 1947 and 1951 respectively and form part of the MNS system. Anti-S and anti-s have both been implicated in Haemolytic Transfusion Reactions and Haemolytic Disease of the Newborn.

The reagents will cause indirect agglutination (clumping) of test red cells, that carry the corresponding specific antigen, in the antiglobulin phase of testing. No agglutination generally indicates the absence of the corresponding specific antigen.

These Monoclonal IgG blood grouping reagents contain human monoclonal antibodies diluted in a phosphate buffer containing sodium chloride and bovine albumin. Each reagent is supplied at optimal dilution for use with all the recommended techniques.