In 1945, Coombs, Mourant and Race described the use of anti-human globulin serum for detecting red cell-bound non-agglutinating antibodies.

When used by recommended techniques, the reagent will cause agglutination (clumping) of red cells, carrying IgG, in the antiglobulin phase of testing. No agglutination usually indicates the absence of IgG.

Lorne Monospecific Anti-Human IgG Clear and Anti-Human IgG Green reagents contain anti-IgG derived from rabbits. All non-specific activity is removed by absorption. The reagent is supplied at optimal dilution for use with spin tube techniques (DAT & IAT).