The Rh blood group system was discovered in 1940. The D antigen is the most clinically significant non-ABO red blood cell antigen and has been implicated in causing Haemolytic Transfusion Reactions and Haemolytic Disease of the Newborn.
The reagents will cause direct agglutination (clumping) of test red cells that carry the D antigen. No agglutination generally indicates the absence of the D antigen.
Lorne Monoclonal IgM Anti-D Clone 1 and Clone 2 blood grouping reagents are low protein reagents containing a human monoclonal IgM antibody diluted with sodium chloride, bovine albumin and macromolecular potentiators. When typing patient samples, each reagent will directly agglutinate Rh D positive cells, including majority of variants (but not DVI) and a high proportion of weak D (Du) phenotypes when using the slide, tube, gel card & microplate techniques.