INFORMATION
Determination of free anti-golimumab antibodies
Golimumab is a recombinant protein used to treat inflammatory bowel disease (IBD). This protein can induce humoral immune responses and lead to anti-drug antibody formation, which is a major cause of loss of drug response. The IDKmonitor Golimumab Free Anti-drug ELISA kit is a microplate-based quantitative sandwich ELISA for the determination of free anti-golimumab antibodies from plasma or serum samples. Detecting high levels of free anti-golimumab antibodies in patients when the drug level is low (undetectable or sub-therapeutic) may indicate poorer long-term outcomes and suggest the need to switch treatment.
KEY ADVANTAGES
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Supports the investigation of primary non-response and loss of response to golimumab
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Highly sensitive assay that only detects free anti-golimumab antibodies
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Total assay time 130 minutes
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May help predict long term outcome of disease
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Applicable to both gastroenterology and rheumatology
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Automatable on ELISA automates (e.g. Dynex DS2)
