PEPTEST is an innovative diagnostic test to help identify Reflux non-invasively. Peptest is based on quantitative lateral flow technology that detects the presence of pepsin in clinical samples from the upper digestive and respiratory tracts.

Gastric juice, containing ingested foods, acid and pepsin, can reflux from the stomach into the oesophagus, larynx and primary airways. Pepsin, the enzyme responsible for the digestion of dietary proteins, is the leading aggressive agent responsible for damage to oesophageal and laryngeal tissue. In excess, gastric reflux can cause a wide range of conditions.

How does Peptest work?

Pepsin that reaches areas outside the stomach is a highly predictive marker of gastric reflux. Saliva and sputm samples can be tested for the presence of Pepsin quickly and non-invasively using Peptest and based on the concentrations found it is possible to determine the severity of reflux.

Peptest utilises a double monoclonal antibody capture technique incorporated into a lateral flow device. Thre results of the test are quantified using a small lateral-flow-reader that can be used in the lab, clinic or GP practice.

Peptest can be used to detect and measure Pepsin in a wide range of clinical samples including:

• Saliva

• Sputum

• Tracheal aspirate

• Oesophageal aspiration

• Gastric juice

• Exhaled air condensate

• Bronchoalveolar fluid

Peptest can help in the following fields of medicine:

Gastroenterology – Peptest helps diagnose and direct treatment in patients suffering from GORD (gastroesophageal reflux disease).

Ear, Nose and Throat (ENT) – For patients suffering with sore throats, persistent coughs, a sensation of a lump in their throat or asthma, Peptest can help in the ENT specialist in their investigations of Laryngopharyngeal reflux (known as “Silent Reflux”). Peptest is a reliable method for diagnosing LPR.

Respiratory – Peptest can also be used for non-acid reflux studies on patients with respiratory conditions. Non-acid reflux is considered one of the commonest causes of chronic cough and is also indicated in voice disorders. In such patients Peptest delivers an objective and quantifiable measure of pepsin to help identify the cause.

Use Peptest to detect the presence of pepsin and help diagnose a wide spectrum of pathological conditions:

• GORD (gastroesophageal reflux)

• LPR (Laryngopharyngeal Reflux)

• Chronic cough

• Cystic fibrosis

• Post-lung transplant rejection

• Asthma

• Sinusitus

• Quantitative Lateral Flow device for the measurement of Pepsin

• Double monoclonal antibody capture technique

• Compatible with wide range of samples (e.g. Saliva, sputum, gastric aspirate, etc.)

• 15 minute assay time

• Box of 50 tests

• Quantify results using Pepcube Reader and data reduction software

• Suitable for laboratory, clinic or GP practice use

• Objectively measure pepsin as a marker for Reflux Disease

• Simple sample collection followed by rapid straight-forward test

• Non-invasive and alternative first line test for e.g. Gastroesophageal reflux disease and Silent reflux

• Beneficial to Gastroenterologists, Ear, Nose and Throat specialists and Respiratory specialists

• Rapid turnaround of results facilitates fast treatment